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| 陳達人 教授兼主任
一、學歷：
中國醫藥大學醫學士
二、經歷：
乳房外科學教授
中國醫藥大學外科部主治醫師
中國醫藥大學醫學研究所教授
彰化基督教醫院乳房中心主任
彰化基督教醫院醫學研究部主任
彰化基督教醫院外科部部協同主任
彰化基督教醫院乳癌小組召集人
台灣乳房醫學會理事
中華民國醫用超音波學會理事
彰化醫師公會醫師教育召集人
國科會研究計劃主持人(2000~2014)
國科會研究計劃審查委員
中山醫學大學醫學系兼任教授
東海大學資工所兼任教授
三、國外進修：
整型式乳癌切除專家訓練課程
-美國達拉斯 (2009)
-法國巴黎外科學院 (2010、2011)
-意大利米蘭EIO (2011、2012、2013)
四、國際醫學期刊審查委員
1、European Radiology特聘審查委員
2、Ultrasound in Medicine & Biology
3、Ultrasound obstetrics & Gynecology
4、Eur.J.Surg.Oncol.
5、Breast Cancer Research and Treatment
五、國際醫學期刊編輯委員
Recent Patents on Medical Imaging
六、國際獎項
1999年國際乳房超音波醫學會(日本東京)青年科學家獎
七、專科證照
1、台灣外科醫學會 外科專科醫師
2、台灣乳房醫學會 乳房專科醫師
3、台灣臨床腫瘤醫學會 臨床腫瘤專科醫師
4、中華民國醫用超音波學會 專科醫師暨專科指導醫師
5、中華民國癌症醫學會 腫瘤外科專科醫師暨腫瘤外科專科指導醫師
八、教職
中華民國教育部審定教授
九、國外演講：
2010 日本東北大學
2011 英國諾丁漢國際整型式乳房切除手術醫學會
2013 日本東京大學
十、論文
國際期刊、原著論文(PUBLICATIONS * corresponding author)
1.Dar-Ren Chen*. An optimized technique for all quadrant oncoplasty in women with small- to medium-sized breasts. European Review for Medical and Pharmacological Sciences 2014， in press
2.Lin C， Hsieh WC， Chen DR， Kuo SJ， Yu WF， Hu SW， Sue HJ， Ko MH， Juan CH， Chung KS， Lin PH.: Hemoglobin adducts as biomarkers of estrogen homeostasis: Elevation of estrogenquinones as a risk factor for developing breast cancer in Taiwanese Women Toxicol Lett. 2014 Jan 19
3.Che Lin， Li-Sheng Chen， Shou-Jen Kuo， Dar-Ren Chen*: Adjuvant tamoxifen influences lipid profile in breast cancer patients. Breast Care 2014， in press.
4.Jia-Long Wu， Hsin-Shun Tseng， Li-Heng Yang， Hwa-Koon Wu， Shou-Jen Kuo， Shou-Tung Chen， Dar-Ren Chen*. Prediction of axillary lymph node metastases in breast cancer patients based on pathologic information of the primary tumor. Medical Science Monitor 2014， in press.
5.Chin-Yuan Chang， Shou-Jen Kuo， Hwa-Koon Wu， Yu-Len Huang， Dar-Ren Chen*. Stellate masses and histologic grades in breast cancer. Ultrasound Med Biol. 2014 Jan 22. pii: S0301-5629(13)01149-6. [Epub ahead of print]
6.Hwa-Koon Wu， Hsin-Shun Tseng， Li-Sheng Chen， Shou-Jen Kuo， Ping-Lang Yen， Yu-Len Huang， Dar-Ren Chen*. Flow index of 3D breast ultrasound was strongly correlated with axillary lymph node metastasis in the absence of lymphovascular invasion. Journal of Medical Imaging and Health Informatics 2014， in press.
7.Wu ju， Li CW， Tsai CH， Chou CW， Chen DR， Wang GJ: Synthesis of Antibacterial TiO2/PLGA composite Biofilms Nanomedicine 2014， in press
8.Tseng HS， Lin C， Chan SE， Chien SY， Kuo SJ， Chen ST， Chang TW， Chen DR*. Pure mucinous carcinoma of the breast: clinicopathologic characteristics and long-term outcome among Taiwanese women World J Surg Oncol. 2013 Jun 14;11:139. doi: 10.1186/1477-7819-11-139.
9.Chao TC， Chen DR， Chao TY， Chen SC， Yeh DC， Wang HC， Huang WT， Rau KM， Chang KJ， Yang TL， Lee KD， Tai CJ， Tseng LM， Hou MF Quality of Life Assessment in Taiwanese Patients with Bone Metastases from Breast Cancer Receiving Zoledronic Acid. Anticancer Res. 2013 Dec;33(12):5543-5547
10.Cheng YS， Kuo SJ， Chen DR*.: Sparing sentinel node biopsy through axillary lymph node fine needle aspiration in primary breast cancers World J Surg Oncol. 2013 Nov 20;11(1):296. [Epub ahead of print]
11.Tseng HS， Lin C， Chan SE， Chien SY， Kuo SJ， Chen ST， Chang TW， Chen DR: Availability of convenience stores and adolescent alcohol use in Taiwan: a multilevel analysis of national surveys.World J Surg Oncol. 2013 Jun 14;11(1):139. [Epub ahead of print]
12.Lai HW， Tseng LM， Chang TW， Kuo YL， Hsieh CM， Chen ST， Kuo SJ， Su CC， Chen DR.: The prognostic significance of metaplastic carcinoma of the breast (MCB) - A case controlled comparison study with infiltrating ductal carcinoma. Breast. 2013 Oct;22(5):968-73. doi: 10.1016/j.breast.2013.05.010. Epub 2013 Jun 17.
13.Kuo YL， Chen WC， Yao WJ， Cheng L， Hsu HP， Lai HW， Kuo SJ， Chen DR*， Chang TW*. Validation of Memorial Sloan-Kettering Cancer Center Nomogram for prediction of Non-sentinel lymph node metastasis in Sentinel lymph node positive Breast Cancer Patients An International Comparison. Int J Surg. 2013 May 21. pii: S1743-9191(13)00119-2. doi: 10.1016/j.ijsu.2013.05.005. [Epub ahead of print]
14.Chen ST， Chen DR， Fang JP， Lin PH.: 2，3，7，8-Tetrachlorodibenzo-p-dioxin modulates estradiol-induced aldehydic DNA lesions in human breast cancer cells through alteration of CYP1A1 and CYP1B1 expression Breast Cancer. 2013 May 23. [Epub ahead of print]
15.Huang YL， Chen DR*， Chang SC. Three-dimensional region-based segmentation for breast tumors on sonography J Ultrasound Med. 2013 May;32(5):835-46. doi: 10.7863/ultra.32.5.835
16.Lai HW， Wu HK， Kuo SJ， Chen ST， Tseng HS， Tseng LM， Chen DR* : Differences in accuracy and underestimation rates for 14 versus 16-gauge core needle biopsies in ultrasound-detectable lesions (Asian J Surg. 2013 Apr;36(2):83-8. doi: 10.1016/j.asjsur.2012.09.003. Epub 2013 Jan 23
17.Shou-Jen Kuo， Hui-Yi Lin， Su-Yu Chien， Dar-Ren Chen*: SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein (Oncol Rep. 2013 Jul;30(1):125-30. doi: 10.3892/or.2013.2470. Epub 2013 May 15)
18.Chen YL， Yan MY， Chien SY， Kuo SJ， Chen DR， Cheng CY， Su CC: Sann-Joong-Kuey-Jian-Tang inhibits hepatocellular carcinoma Hep-G2 cell proliferation by increasing TNF-α， Caspase-8， Caspase- 3 and Bax but by decreasing TCTP and Mcl-1 expression in vitro Mol Med Rep. 2013 Mar 20. doi: 10.3892/mmr.2013.1381. [Epub ahead of print]
19.Chien SY， Kuo SJ， Chen DR， Su CC.: Sann-Joong-Kuey-Jian-Tang decreases the protein expression of Mcl 1 and TCTP and increases that of TNF-α and Bax in BxPC 3 pancreatic carcinoma cellsInt J Mol Med. 2013 Jul;32(1):85-92. doi: 10.3892/ijmm.2013.1369. Epub 2013 May 8
20.Lin C， Chen DR， Hsieh WC， Yu WF， Lin CC， Ko MH， Juan CH， Tsuang BJ， Lin PH: Investigation of the cumulative body burden of estrogen-3，4-quinone in breast cancer patients and controls using albumin adducts as biomarkers. Toxicol Lett. 2013 Feb 17;218(3):194-199. doi: 10.1016/j.toxlet.2013.02.004. [Epub ahead of print
21.Liao SF， Li SH， Huang HY， Chen ST， Kuo SJ， Chen DR， Wei TS.: The efficacy of complex decongestive physiotherapy (CDP) and predictive factors of lymphedema severity and response to CDP in breast cancer-related lymphedema (BCRL).Breast. 2013 Jan 12. doi:pii: S0960-9776(12)00262-7. 10.1016/j.breast.2012.12.018. [Epub ahead of print]
22.Huang CY， Chiu TL， Kuo SJ， Chien SY， Chen DR， Su CCTanshinone IIA inhibits the growth of pancreatic cancer BxPC 3 cells by decreasing protein expression of TCTP， MCL 1 and Bcl xLMol Med Report. 2013 Jan 25. doi: 10.3892/mmr.2013.1290. (Epub ahead of print)
23.Tsai HT， Yang SF， Chen DR， Chan SE.: CCL5-28， CCL5-403， and CCR5 genetic polymorphisms and their synergic effect with alcohol and tobacco consumptions increase susceptibility to hepatocellular carcinoma Med Oncol. 2012 Dec;29(4):2771-9. doi: 10.1007/s12032-012-0189-9. Epub 2012 Feb 29.
24.Yang LH， Tseng HS， Lin C， Chen LS， Chen ST， Kuo SJ， Chen DR*: Survival Benefit for Tamoxifen in Estrogen Receptor Negative and Progesterone Receptor Positive Low Grade Breast Cancer J Breast Cancer. 2012 Sep;15(3):288-95. doi: 10.4048/jbc.2012.15.3.288. Epub 2012 Sep 28.
25.Wu CT， Cheng YH， Chen FN， Chen DR， Wei MF， Chang NW: Combined effects of peroxisome proliferator-activated receptor alpha and apolipoprotein e polymorphisms on risk of breast cancer in a taiwanese population J Investig Med. 2012 Dec;60(8):1209-13. doi: 10.231/JIM.0b013e31826be86a
26.Chang NW， Wu CT， Chen DR， Yeh CY， Lin C: High levels of arachidonic acid and peroxisome proliferator-activated receptor-alpha in breast cancer tissues are associated with promoting cancer cell proliferationJ Nutr Biochem. 2012 Aug 16. [Epub ahead of print]
27.Lee YP， Tsai WC， Ko CJ， Rao YK， Yang CR， Chen DR， Yang MH， Yang CC， Tzeng YM: Anticancer effects of eleven triterpenoids derived from Antrodia camphorata Anticancer Res. 2012 Jul;32(7):2727-34.
28.Kuo YL， *Chen DR， Chang TW. Accuracy validation of adjuvant! online in Taiwanese breast cancer patients - a 10-year analysis. BMC Medical Informatics and Decision Making 2012 Sep 17;12(1):108
29.Baselga J， Bradbury I， Eidtmann H， Di Cosimo S， de Azambuja E， Aura C，Chen DR， Hickish T， Patel A， Chan S， Roylance R. : NeoALTTO Study Team Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised， open-label， multicentre， phase 3 trial. Lancet. 2012 Feb 18;379(9816):633-40. doi: 10.1016/S0140-6736(11)61847-3. Epub 2012 Jan 17
.
30.Yen PL ，Ho HK，Tseng HS， KUO SJ， Huang YL， PhD， Hong-Ting Chen HT， Chen DR* Vascular morphologic information of three dimensional power Doppler ultrasound is valuable in the classifications of breast lesions. Clin Imaging. 2012 Jul-Aug;36(4):267-71. doi: 10.1016/j.clinimag.2011.11.012. Epub 2012 Jun 8.
31.Shou-Tung Chen， Shou-Jen Kuo， Hwa-Koon Wu， Li-Sheng Chen， Dar-Ren Chen*: Power Doppler breast ultrasound: Association of vascularization and ER/c-erbB-2 co-expression in invasive breast carcinoma Breast Cancer. 2011 Nov 29
32.Tseng HS， Wu HK， Chen ST， Kuo SJ， Huang YL， Chen DR*: Speckle Reduction Imaging of Breast Ultrasound Does Not Improve the Diagnostic Performance in Morphology Based CAD System (J Clin Ultrasound. 2012 Jan;40(1):1-6. )
33.Shou-Tung Chen， Hung-Wen Lai， Hsin-Shun Tseng， Li-Sheng Chen， Shou-Jen Kuo， Dar-Ren Chen*: Correlation of histologic grade with other clinicopathological parameters， intrinsic subtype， and patients’ clinical outcome in Taiwanese women Jpn J Clin Oncol. 2011 Dec;41(12):1327-35..
34.Chang NW， Chen DR， Chen FN， Lin C， Wu CT: HER2 Codon 655 G-Allele Is Associated With Reductions in Plasma High-Density Lipoprotein Levels in Breast Cancer Patients Treated With Tamoxifen J Investig Med. 2011 Dec;59(8):1252-7
35.Chien SY， Kuo SJ， Chen YL， Chen DR， Cheng CY， Su CC: Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo. Mol Med Report. 2011 Oct 14. doi: 10.3892/mmr.2011.631. [Epub ahead of print]
36.Yan MY， Chien SY， Kuo SJ， Chen DR， Su CC. Tanshinone IIA inhibits BT-20 human breast cancer cell proliferation through increasing caspase 12， GADD153 and phospho-p38 protein expressionInt J Mol Med. 2012 Feb 7. doi: 10.3892/ijmm.2012.908. [Epub ahead of print]
37.Chang HC， Chen ST， Chien SY， Kuo SJ， Tsai HT， Chen DR*: Capsaicin may induce breast cancer cell death through apoptosis-inducing factor involving mitochondrial dysfunctionHum Exp Toxicol. 2011 Oct;30(10):1657-65. Epub 2011 Feb 7
38.Chen CJ， Lin SE， Lin YM， Lin SH， Chen DR*， Chen CL.: Association of Expression of Kruppel-Like Factor 4 and Kruppel-Like Factor 5 with the Clinical Manifestations of Breast Cancer. Pathol Oncol Res. 2011 Jun 15. [Epub ahead of print]
39.Chan SE， Lai HW， Su CC， Kuo SJ， Chien SY， Lin HY， Chen DR*: Effect of Supplementation of Tanshinone IIA and Sodium Tanshinone IIA Sulfonate on the Anticancer Effect of Epirubicin: An In Vitro Study Evid Based Complement Alternat Med. 2011;2011:841564. Epub 2011 May 24
40.Hung-Wen Lai， Su-Yu Chien， Shou-Jen Kuo， Ling-Ming Tseng， Chin-Wen Chi， Dar-Ren Chen* and Hui-Yi Lin.: The Potential Utility of Curcumin in the Treatment of HER-2-overexpressed Breast Cancer- An in vitro and in vivo Comparison Study with Herceptin， (Evid Based Complement Alternat Med. 2012;2012:486568. Epub 2011 Jun 6)
41.Yen PL， Chen DR， Yeh KT， Chu PY: Development of a stiffness measurement accessory for ultrasound in breast cancer diagnosis Med Eng Phys. 2011 May 27. [Epub ahead of print]
42.Dar-Ren Chen*， Hung-Wen Lai: Three-dimensional Breast Ultrasound for Malignt Detection ( invited review article， Expert Opinion on Medical Diagnostics)
43.Hung-Wen Lai， Shou-Jen Kuo， Sam Li-Sheng Chen， Chin-Wen Chi， Shou-Tung Chen， Tsai-Wang Chang， Dar-Ren Chen*: Prognostic significance of triple negative breast cancer at tumor size 1 cm and smaller (Eur J Surg Oncol. 2011 Jan;37(1):18-24. Epub 2010 Nov 19)
44.C. Lin， D. R. Chen* ，Chang KJ，Chang TW，Wang HC: The Pathologic Complete Response Rate and Toxicity Profile of Combination Docetaxel with Cisplatin plus Trastuzumab in T2 Breast Cancer Patients – A phase II study (In press， Cancer Chemotherapy and Pharmacology)
45.Nai-Wen Chang， Dar-Ren Chen， Fei-Na Chen， Chingju Lin， Chen-Teng Wu: HER2 codon 655 Val allele decreases plasma HDL-cholesterol levels in breast cancer patients with tamoxifen therapy J Investig Med. 2011 Dec;59(8):1252-7. doi: 10.231/JIM.0b013e3182354923.
46.Lin C， Chien SY， Kuo SJ， Chen LS， Chen ST， Lai HW， Chang TW， Chen DR*: A 10-year Follow-up of Triple-negative Breast Cancer Patients in Taiwan Jpn J Clin Oncol. 2012 Jan 27. [Epub ahead of print]
47.Yao-Lung K， Dar-Ren C， Tsai-Wang C: Clinicopathological features of triple-negative breast cancer in Taiwanese Women Int J Clin Oncol. 2011 Apr 1. [Epub ahead of print]
48.Chen DR， Chen ST， Wang TW， Tsai CH， Wei HH， Chen GJ， Yang TC， Lin C， Lin PH.: Characterization of estrogen quinone-derived protein adducts and their identification in human serum albumin derived from breast cancer patients and healthy controls. Toxicol Lett. 2011 Feb 24 [Epub ahead of print]
49.D.-R. Chen， I.-P. Lien， Y.-L. Huang: Ultrasonic vascularization evaluation in breast cancer with neoadjuvant chemotherapy Int J CARS (2011) 6 (Suppl 1):S305–S366
50.Wu HS， Lai HW， Kuo SJ， Lee YT， Chen DR， Chi CW， Huang MH.: Competitive Edge of Laparoscopic Appendectomy Versus Open Appendectomy: A Subgroup Comparison Analysis. J Laparoendosc Adv Surg Tech A. 2011 Feb 1. [Epub ahead of print
51.Chen DR， Chien SY， Kuo SJ， Teng YH， Tsai HT， Kuo JH， Chung JG: SLC34A2 as a novel marker for diagnosis and targeted therapy of breast cancer ( Anticancer Res. 2010 Oct;30(10):4135-40
52.Chen DR， Huang YL， Lin SH : Computer-aided Diagnosis with Textural Features for Breast Lesions in Sonograms (Comput Med Imaging Graph. 2010 Dec 3. [Epub ahead of print] )
53.Chang HC， Chen ST， Chien SY， Kuo SJ， Tsai HT， Chen DR*: Capsaicin may induce breast cancer cell death through apoptosis-inducing factor involving mitochondrial dysfunction Hum Exp Toxicol. 2011 Feb 7
54.Hsin-Shun Tseng， Szu-Erh Chan， Shou-Jen Kuo， Dar-Ren Chen*: Acupuncture-related rapid dermal spread of breast cancer: a rare case J Breast Cancer. 2011 Dec;14(4):340-4. Epub 2011 Dec 27)
55.Wu YC， Tang CS， Huang HY， Liu CH， Chen YL， Chen DR， Lin YW: Chemical production in electrocautery smoke by a novel predictive model Eur Surg Res. 2011;46(2):102-7. Epub 2011 Jan 11
56.Chu-Chung Chou， Jai-Sing Yang， Hsu-Feng Lu， Siu-Wan Ip， Chyi Lo Chih-Chung Wu， Jing-Pin Lin， Nou-Ying Tang， Jing-Gung Chung， Ming-Jen Chou， Ying-Hock Teng， and Dar-Ren Chen*: Quercetin-mediated Cell Cycle Arrest and Apoptosis Involving Activation of a Caspase Cascade through the Mitochondrial Pathway in Human Breast Cancer MCF-7 Cells Arch Pharm Res Vol 33， No 8， 1181-1191， 2010
57.Kuo SJ， Chen TH， Yen AM， Chen DR， Chen LS. Optimal two-stage breast cancer screening for countries with intermediate or low incidence of breast cancer. J Eval Clin Pract. 2010 Aug 24. [Epub ahead of print]
58.Lu YS， Chen DR， Tseng LM， Yeh DC， Chen ST， Hsieh CM， Wang HC， Yeh HT， Kuo SH， Huang CS: Phase II study of docetaxel， capecitabine， and cisplatin as neoadjuvant chemotherapy for locally advanced breast cancer. Cancer Chemother Pharmacol. 2010 Aug 11. [Epub ahead of print]
59.Kuo SJ， Chien SY， Lin C， Chan SE， Tsai HT， Chen DR*.: Significant elevations of CLDN16 and HAPLN3 gene expression in human breast cancer tissue Oncol Rep. 2010 Sep;24(3):759-66.
60.Che Lin， Su-Yu Chien， Dar-Ren Chen*: Nandrolone Abuse Aggravates Septic Shock (Kaohsiung J Med Sci. 2011 Jun;27(6):222-9. Epub 2011 Mar 31.
61.Yao-Li Chen， Hsin-Shun Tseng， Wu-Hsien Kuoe， Shun-Fa Yang， Dar-Ren Chen*， Hsiu-Ting Tsai* : Glutathione S-Transferase P1 (GSTP1) Gene Polymorphism Increases Age-Related Susceptibility of Hepatocellular Carcinoma ( BMC Genomics 2010， 11:46)
62.Yu-Chen Lee， Yao-Li Chen， Szu-Erh Chan， Hsin-Shun Tseng， Dar-Ren Chen*: Neuroendocrine Carcinoma of the Breast: Case Report and Literature Review ( Breast Care 2009;4:324-327)
63.Su-Yu Chien， Yao-Chung Wu， Jai-Sing Yang ， Hsu-Feng Lu， Mei-Fen Tsou， W. G. Wood， Jing-Gung Chung， Dar-Ren Chen: Quercetin induced apoptosis acts through mitochondrial- and caspase-3- dependent pathways in human breast cancer MDA-MB-231 cells. Hum Exp Toxicol. 2009 Aug;28(8):493-503. Epub 2009 Sep 15
64.Po-Hsiung Lin， Dar-Ren Chen， Tzu-Wen Wang， Chia-Hua Lin， Ming-ChiehChuang， Po-Hsiung Lin: Investigation of the Cumulative Tissue Doses of Naphthoquinones in Human Serum Using Protein Adducts as Biomarker of Exposure Chem Biol Interact. 2009 Sep 14;181(1):107-14. Epub 2009 Jun 6.
65.Chia-Hua Lin， Ching-Lung Huang， Ming-Chieh Chuang， Ying-Jan Wang， Dar-Ren Chen， Shou-Tung Chen， and Po-Hsiung Lin: Protective Role of Estrogen Receptor-alpha on Lower Chlorinated PCB Congener-Induced DNA Damage and Repair in Human Tumoral Breast Cells (Toxicol Lett. 2009 Jul 10;188(1):11-9. Epub 2009 Feb 20)
66.Chen ST， Yi-Hsuan Hsiao， Yu-Len Huang， Wen-Miin Liang， Shou-Jen Kuo， Ming-Jen Chou， Dar-Ren Chen*: Comparative Analysis of Logistic Regression， Support Vector Machines and Artificial Neural Networks for 3D Power Doppler Imaging of Solid Breast Tumors. Korean J Radiol. 2009 Sep-Oct;10(5):464-71. Epub 2009 Aug 25.
67.Lin C， Chien SY， Chen LS， Kuo SJ， Chang TW， Chen DR*: Triple Negative Breast Carcinoma is a Prognostic Factor in Taiwanese Women. BMC Cancer. 2009 Jun 18;9(1):192. [Epub ahead of print]
68.Yu-Len Huang*， Chia-Chia Hsu， Yi-Hsuan Hsiao， Dar-Ren Chen*: Computer-aided Diagnosis for Breast Tumors by Using Vasculization of 3-D Power Doppler Ultrasound Ultrasound Med Biol. 2009 Oct;35(10):1607-14. Epub 2009 Aug 3.
69.Chang NW， Chen FN， Wu CT， Clin-Fen Lin， Chen DR*:Apolipoprotein E4 allele influences the response of plasma triglyceride levels to tamoxifen in breast cancer patients Clinica Chimica Acta 401 (2009) 144–147
70.Chu-Chung Chou， Yao-Chung Wu， Yu-Fen Wang， Ming-Chih Chou， Shou-Jen Kuo， Dar-Ren Chen*: Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway (Oncol Rep. 2009 Mar;21(3):665-71)
71.Yi-Hsuan Hsiao， Yu-Len Huang， Wen-Miin Liang， Shou-Jen Kuo， Dar-Ren Chen*: Characterization of Benign and Malignant Solid Breast Masses: Harmonic versus Non-harmonic 3D Power Doppler Imaging (Ultrasound Med Biol. 2009 Mar;35(3):353-9. Epub 2008 Nov 28.)
72.Tseng HS， Chen YL， Chen ST， Wu YC， Kuo SJ， Chen LS， Wu HK， Chen DR*: The Management of Papillary Lesion of the Breast by Core-needle Biopsy. EJSO 35 (2009) 21-24
73.Yen PL， Chen DR， Yeh KT， Chu PY.: Lateral exploration strategy for differentiating the stiffness ratio of an inclusion in soft tissue. Med Eng Phys. 2008 Oct;30(8):1013-9. Epub 2008 May 20.
74.Chen D， Chu CY， Chen CY， Yang HC， Chiang YY， Lin TY， Chiang IP， Chuang DY， Yu CC， Chow KC: Expression of short form oncostatin M receptor as a decoy in lung adenocarcinomas (J Pathol. 2008 Jul;215(3):290-9)
75.Shou-Jen Kuo， Yu-Len Huang， Yi-Hsuan Hsiao， Dar-Ren Chen* : Vasculization of 3D Power Doppler Ultrasound Applied to Classify Benign and Malignant Breast Tumors by Using Neural Networks Ultrasound Obstet Gynecol. 2008 Jul;32(1):97-102
76.Yi-Hsuan Hsiao， Yu-Len Huang， Shou-Jen Kuo， Wen-Miin Liang，， Shou-Tong Chen， Dar-Ren Chen: Characterization of Benign and Malignant Solid Breast Masses in Harmonic 3D Power Doppler Imaging Eur J Radiol. 2009 Jul;71(1):89-95. Epub 2008 May 14.
77.Kuo SJ， Wang HC， Chow KC， Chiou SH， Chiang SF， Lin TY， Chiang IP， Chen DR*: Nuclear expression of rTSβ as a novel 5-fluorouracil resistance marker in patients with primary breast cancer Oncol Rep. 2008 Apr;19(4):881-8
78.Dar-Ren Chen， Yi-Hsuan Hsiao: Computer-Aided Diagnosis for Breast Ultrasound ( J Med Ultrasound 2008;16(1):46–56) Review Article
79.Huang SF， Chang RF， Moon WK， Lee YH， Chen DR， Suri JS.: Analysis of tumor vascularity using three-dimensional power Doppler ultrasound images. IEEE Trans Med Imaging. 2008 Mar;27(3):320-30
80.Yi-Hsuan Hsiao， Shou-Jen Kuo， Wen-Miin Liang， Yu-Len Huang， Dar-Ren Chen* : Intra-tumor Flow Index Can Predict the Malignant Potential of Breast Tumor: Dependent on Age and Volume (Ultrasound Med Biol. 2008 Jan;34(1):88-95)
81.Huang YL， Chen DR， Jiang YR， Kuo SJ， Wu HK， Moon WK.: Computer-aided Diagnosis with Morphological features for Breast Lesion on Sonograms Ultrasound Obstet Gynecol. 2008 Sep;32(4):565-72.
82.Yung-Hsien Liu， Mu-Tai Liu1， Dar-Ren Chen， Wen-Tao Huang， Ai-Yih Wang， Wen-Shan Liu， Tung-Hao Chang， Chu-Ping Pi， Chao-Yuan Huang: Occult Breast Cancer Presenting Aa Axillary Nodal Metastasis - A Case Report and Review of the Literature Therapeut Radiol Oncol 2007; 14(1): 57-62
83.Chang RF， Chang-Chien KC， Takada E， Suri JS， Moon WK， Wu JK， Cho N， Wang YF， Chen DR.: Breast Density Analysis in 3-D Whole Breast Ultrasound Images Conf Proc IEEE Eng Med Biol Soc. 2006;1(1):2795-2798.
84.Chang RF， Chang-Chien KC， Takada E， Suri JS， Moon WK， Wu JK， Cho N， Wang YF， Chen DR.: Three Comparative Approaches for Breast Density Estimation in Digital and Screen Film Mammograms Conf Proc IEEE Eng Med Biol Soc. 2006;1(1):4853-4856.
85.Hsien-Wen Kuo， Suze-Yuan Chou， Tsung-Wen Hu， Fang-Yang Wu， Da-Jen Chen: Urinary 8-hydroxy-2’ -deoxyguanosine _ (8-OHdG) and genetic polymorphisms in breast cancer Mutat Res. 2007 Jul 10;631(1):62-8.
86.Jeffery H.K. Wu， Ruey-Feng Chang， Ching-Lin Wang， Cheng-Shyong Chang， Shou-Jen Kuo， Shou-Tung Chen， Woo Kyung Moon， Ta-Hsun Kuo， Dar-Ren Chen*: Tamper Detection and Recovery for Medical Image Using Nearly Lossless Information Hiding Technique J Digit Imaging. 2008 Mar;21(1):59-76
87.Chang RF， Huang SF， Moon WK， Lee YH， Chen DR: Solid Breast Masses: Neural Network Analysis of Vascular Features at Three-dimensional Power Doppler US for Benign or Malignant Classification. Radiology. 2007 Apr;243(1):56-62. Epub 2007 Feb 20.
88.Chang RF， Huang SF， Wang LP， Chen D， Moon W.: Microcalcification detection in 3-d breast ultrasound Conf Proc IEEE Eng Med Biol Soc. 2005;6:6297-300
89.Y. L. Huang， D.R. Chen: Automatic contouring for breast tumors in 2-d sonography. Conf Proc IEEE Eng Med Biol Soc. 2005;3:3225-8.
90.Y. L. Huang， S.H. Lin， D.R. Chen:Computer-Aided Diagnosis Applied to 3-D US of Solid Breast Nodules by Using Principal Component Analysis and Image Retrieval. Conf Proc IEEE Eng Med Biol Soc. 2005;2:1802-5.
91.Y. L. Huang， K. L. Wang ， D. R. Chen， "Diagnosis of Breast Tumors with Ultrasonic Texture Analysis Using Support Vector Machines"， Neural Computing and Applications， vol. 15， no. 2， pp.164-169， Apr. 2006. (NSC 93-2213-E-029-014)
92.Huang YL， Jiang YR， Chen DR， Moon WK: Level Set Contouring for Breast Tumor in Sonography. J Digit Imaging. 2007 Jan 24; [Epub ahead of print]
93.Wu HD， Chou SY， Chen DR， Kuo HW: Differentiation of serum levels of trace elements in normal and malignant breast patients Biol Trace Elem Res. 2006 Oct;113(1):9-18
94.Chang RF， Huang SF， Moon WK， Lee YH， Chen DR: Computer algorithm for analysing breast tumor angiogenesis using 3-D power Doppler ultrasound Ultrasound Med Biol.2006 Oct;32(10):1499-508
95.Chen CJ， Chang RF， Moon WK， Chen DR*: 2-D ultrasound strain images for breast cancer diagnosis using nonrigid subregion registration. Ultrasound Med Biol. 2006 Jun;32(6):837-46.
96.Wu YC， Chen DR*， Kuo SJ Personal Experience of Ultrasound-guide 14 gauge Core Biopsy of Breast Tumor Eur J Surg Oncol. 2006 Jun 32(7); 715-718
97.Shou-Jen Kuo， Dar-Ren Chen*: Expression of glucose transporter-1 in Taiwanese patients with breast carcinoma – a preliminary report. Kaohsiung J Med Sci. 2006 Jul;22(7):339-45
98.Woo Kyung Moon， Ruey-Feng Chang， Chii-Jen Chen， Wei-Liang Chen， Dar-Ren Chen*:Solid breast masses: classification with computer-aided analysis of continuous US images obtained with probe compression Radiology. 2005 Aug;236(2):458-64
99.Shou-Jen Kuo ， Kung-Tao Yang， Dar-Ren Chen*: Objective and Noninvasive Detection of Sub-clinical Lung Injury in Breast Cancer Patients after Radiotherapy Eur J Surg Oncol. 2005 Nov;31(9):954-7.
100. Hung YL， Kuo SJ， Chang CS， Lieu YK， Moon WK， Chen DR*: Image Retrieval with Principal Component for Breast Cancer Diagnosis on Various Ultrasound System Ultrasound Obstet Gynecol. vol. 26， no. 5， pp.558-566， October 2005
101. Chen DR*， Chang RF， Chen CJ， Ho MF， Kuo SJ， Chen ST， Hung SJ， Moon WK: Classification of breast ultrasound images using fractal feature. Clin Imaging. 2005 Jul-Aug;29(4):235-45
102. Chen WM， Chang RF， Kuo SJ， Chang CS， Moon WK， Chen ST， Chen DR*: 3-D ultrasound texture classification using run difference matrix Ultrasound Med Biol. 2005 Jun;31(6):763-70
103. Huang YL， Chen DR: Support vector machines in sonography Application to decision making in the diagnosis of breast cancer. Clin Imaging. 2005 May-Jun;29(3):179-84
104. Chang NW， Chen DR， Wu CT， Aouizerat BE， Chen FN， Hung SJ， Wang SH， Wei MF， Chang CS: Influences of apolipoprotein E polymorphism on the risk for breast cancer and Her2/neu status in Taiwan. Breast Cancer Res Treat. 2005 Apr;90(3):257-61
105. Ruey-Feng Chang， Wen-Jie Wu， Dar-Ren Chen*， Woo Kyung Moon: Mophology Based Automatic Ultrasound Segmentation and Diagnosis of Solid Breast Tumors. Breast Cancer Res Treat. 2005 Jan;89(2):179-85
106. Yu-Len Hung， Dar-Ren Chen: Watershed Segmentation for Breast Tumor in 2-D Sonography. Ultrasound in Medicine & Biology 2004 May; 30(5): 625-632
107. Dar-Ren Chen*， Ruey-Feng Chang， Chii-Jen Chen， Chih-Chia Chang， Long-Bin Jeng: Three-dimensional ultrasound in margin evaluation for breast tumor excision using Mammotome. Ultrasound in Medicine & Biology 2004 February 30(2): 169-179
108. Lee JH， Lu HF， Wang DY， Chen DR， Su CC， Chen YS， Yang JH， Chung JG. : Effects of tamoxifen on DNA adduct formation and arylamines N-acetyltransferase activity in human breast cancer cells. Res Commun Mol Pathol Pharmacol. 2004;115-116:217-33.
109. Huang SF， Chang RF， Chen DR， and Moon WK: Detection of Spiculation in Three- Dimensional Breast Ultrasound， IEEE Trans Med Imaging. 2004 Jan; 23(1): 111-21
110. Chang RF， Wu WJ， Moon WK， Chen WM， Lee W， Chen DR*: Segmentation of breast tumor in three-dimensional ultrasound images using three-dimensional discrete active contour model. Ultrasound Med Biol. 2003 Nov; 29(11):1571-81
111. Chen WM， Chang RF， Moon WK， Chen DR*: Segmentation of Breast Tumor in 3D Ultrasound Images Using 3D Discrete Active Contour Model. Ultrasound in Medicine & Biology 2003 July; 29(7): 1027-1035.
112. Chang RF， Wu WJ， Tseng CC， Chen DR， Moon WK: 3D Snake for US in Margin Evaluation for Malignant Breast Tumor Excision Using Mammotome. IEEE Trans Inf Technol Biomed. 2003 Sep;7(3):197-201
113. Chen WM， Chang RF， Moon WK， Chen DR*: Breast cancer diagnosis using three-dimensional ultrasound and pixel relation analysis. Ultrasound in Medicine & Biology 2003 July; 29(7): 1027-1035.
114. Chen DR*， Chang RF， Wu WJ， Moon WK， Wu WL: 3-D breast ultrasound segmentation using active contour model. Ultrasound in medicine & biology 2003 July; 29(7): 1017-1026.
115. Chang RF， Wu WJ， Chen DR*， Chen WM， Shu W， Lee JH， Jeng LB: 3-D US frame positioning using speckle decorrelation and image registration. Ultrasound in Medicine & Biology 2003 June; 29(6): 801-812.
116. Ruey-Feng Chang， Wen-Jie Wu， Woo Kyung Moon， Dar-Ren Chen*: Improvement in breast tumor discrimination by support vector machines and speckle-emphasis texture analysis. Ultrasound In Medicine & Biology 2003 May; 29(5): 679-686.
117. Dar-Ren Chen*， Ruey-Feng Chang， Wei-Ming Chen， Woo Kyung Moon: Computer Aided Diagnosis for Three-Dimensional Breast Ultrasound. Archives of Surgery 2003 March; 138(3): 296-302.
118. Ruey-Feng Chang， Wen-Jie Wu， Woo Kyung Moon Dar-Ren Chen*: Support Vector Machines for Diagnosis of Breast Tumor in Ultrasonic Images. Academic Radiology 2003 February; 10(2): 189-197.
119. Chen DR， Jeng LB， Kao A.， Lin CC， Lee CC: Comparing Thallium-201 Spect Mammoscintigraphy and Ultrasonography to Detect Breast Cancer in Mammographical Dense Breasts. Neoplasma 2003; 50(3): 222-226.
120. Fang-Yang Wu， Yi-Ju Lee， Dar-Ren Chen， Hsien-Wen Kuo: Association of DNA-protein crosslinks and breast cancer. Mutation Research， 2002， 501: 69-78.
121. Hsein Wen Kuo， Sun Fan Chen， Wu Chin Ching， Dar-Ren Chen， Jau Hung Lee: Serum and Tissue Trace Element in Patient with breast Cancer in Taiwan. Biological Trace Element Research 2002 89(1): 1-11.
122. Wang HC， Chen DR， Kao CH， Lin CC， Lee CC: Detecting breast cancer in mammographically dense breasts: comparing technetium-99m tetrofosmin mammoscintigraphy and ultrasonography. Cancer Investigation 2002; 20(7-8): 932-8.
123. Chen DR， Jeng LB， Kao A， Lin CC， Lee CC: Usefulness of ammoscintigraphy with thallium-201 single photon emission computed tomography to differentiate palpable breast masses of young Taiwanese women when comparing with mammography. Neoplasma 2002; 49(5): 334-337.
124. Dar-Ren Chen*， Ruey-Feng Chang， Wen-Jia Kuo， Ming-Chun Chen， and Yu-Len Huang: Ultrasonic Medical Image Diagnosis of Breast Tumors Using Wavelet Transform and Neural Networks. Ultrasound in Medicine & Biology 2002 October; 28(10): 1301-1310.
125. Dar-Ren Chen*， Ruey-Feng Chang， Jau-Hong Lee: Three-Dimensional Breast
Ultrasound Imaging in Patient with Nipple Discharge: A pictorial review of 27 cases. Journal of Medical Ultrasound， 2002; 10(2): 69-75.
126. Dar-Ren Chen*， Wen-Jia Kuo， Ruey-Feng Chang， Woo Kyung Moon ， Cheng Chun Lee: Computer-aided Diagnostic Sonomammography with Bootstrap Technique for Small Training Sets. Ultrasound in Medicine & Biology 2002; 7: 897-902.
127. Wen-Jia Kuo， Ruey-Feng Chang， Cheng Chun Lee， Woo Kyung Moon， Dar-Ren Chen* : Retrieval Technique for the Diagnosis of Solid Breast Tumor on Sonogram. Ultrasound in Medicine & Bology 2002; 7: 903-909.
128. Kim-Choy Ng， Chee-Keong Tan， Shih-Wei Lai， Dar-Ren Chen， Wei-Kung Chen: Mucocele of the Appendix with Hematuria. The Yale journal of biology and medicine 2001; 74: 9-12
129. Wen-Jia Kuo， Ruey-Feng Chang， Dar-Ren Chen*， Woo Kyung Moon: Computer-aided Diagnosis of Breast Tumors with Different Ultrasound Systems. Academic Radiology 2002; 9:793-799.
130. Dar-Ren Chen*， Ruey-Feng Chang， Tz-Yi Lin， Mei-DueYang: Papillary Disease of Breast: High Resolution US and 3D Imaging Appearances. Journal of Medical Ultrasound， 2001; 9(3): 147-149.
131. Wen-Jia Kuo， Ruey-Feng Chang， Dar-Ren Chen*， Cheng Chun Lee: Data Mining with Decision Trees for Diagnosis of Breast Tumor in Medical Ultrasonic Images. Breast Cancer Research and Treatment， 2001; 66:51-57.
132. Shian-Min Liu and Dar-Ren Chen: Signet-ring Cell Carcinoma of the Breast. Pathology International 2000; 500: 67-70.
133. Dar-Ren Chen*， Ruey-Feng Chang， Yu-Len Huang， Yi-Hong Chou， Chui-Mei Tiu， Po-Pang Tsai: Texture Analysis of Breast Tumors on Sonograms. Seminars in Ultrasound， CT and MR 2000; 4(21): 308-316.
134. Ruey-Feng Chang， Wen-Jia Kuo， Dar-Ren Chen*， Yu-Len Huang， Jau-Hong Lee， Yi-Hong Chou: Computer-Aided Diagnosis for Surgical Office-Based Breast Ultrasound. Archives of Surgery 2000; 135: 696-699.
135. Dar-Ren Chen*， Ruey-Feng Chang， Yu-Len Huang: Breast Cancer Diagnosis Using Self-Organizing Map for Sonography. Ultrasound in Medicine & Biology 2000; 3: 405-411.
136. Yung-Fanng Chen， Hsein-Jar Chiang， Jan-Horng Lee， Dar-Ren Chen， Chung-Yi Lin， Yuan-Horng Tzeng， Ruey-Fen Chen: Percutaneous Transhepatic Removal of Bile Duct Stones Chin J Radiol 2000; 25:1-5
137. Dar-Ren Chen*， Ruey-Feng Chang， Yu-Len Huang: Computer-aided Diagnosis applied to US of Solid Breast Nodules by Using Neural Networks. Radiology 1999; 213: 407-412.
138. Dar-Ren Chen*， Kuo-Juei Lin.， Wen-Miin Liang， Hsien-Wen Kuo， Rey-Feng Chang: Computerized Quantitative Assessment of Sonomammographic Homogeneity between Fibroadenoma and Carcinoma of Breast. Journal of Medical Ultrasound 1999; 7:157-162
139. Dar-Ren Chen*， Ruey-Feng Chang， Hsien-Wen Kuo， Kuo-Juei Lin， Jau- Hong Lee: Computerized Quantitative Assessment of Echogenicity of Breast Fibroadenoma. Journal of Medical Ultrasound 1999; 7: 11-17).
140. Kim-Choy Ng， Jau-Hong Lee， Dar-Ren Chen， Ke-Chang Huang: A Rare Cause of Obstructive Jaundice-Biliary Tuberculosis Associated with Intrahepatic Stone. Medical Journal of China Medical College and Hospital 1997; 2:192-197
141. Jau-Hong Lee， Dar-Ren Chen， Shin-Cheng Pang， Yih-Syhong Lai: Mucinous Biliary Cysadenoma with mesenchymal stroma; Expression of CA 19-9 and CEA in the serum and cystic fluid. Journal of Gastroenterology. 1996; 31:732 |
國內首創推廣整型式乳癌切除手術
乳癌超音波診斷暨微創手術
乳癌相關之化療、標靶治療及賀爾蒙治療
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